LECTURE 22/02/22

The Association between Periodontitis and Alzheimer’s Disease

Prof Nicola West

Professor Nicola West


DATE: 22/02/2022

TIME: Refreshments and Trade Show from 6.30 p.m. Lecture from 7p.m.


The Royal College of Physicians

11 St Andrews Place, London NW1 4LE


There is compelling evidence to suggest a strong link between periodontitis and late onset Alzheimer’s disease (LOAD). This includes studies showing a relationship between periodontal health, including levels of circulating antibodies to periodontal pathogens, and cognitive impairment, as well as large- scale population studies. The aetiology of LOAD is known to have a large inflammatory component mediated by the innate immune system in the brain.

Chronic peripheral inflammation such as that caused by periodontitis may have a role in activation of inflammatory processes in the brain and subsequent LOAD associated pathology, but additionally, the direct incursion of microbial pathogens, including periodontal bacteria, into the CNS may have an important role. This presentation will review the literature on the association between periodontal disease and Alzheimer’s Disease and discuss recent research on characterisation of bacterial populations found in post-mortem brain samples from areas relevant to early and late stages of AD pathology. Treatment of a patient with early dementia will also be covered.

Educational Aims and Objectives

The presentation will:

  • Review the literature on the association between periodontal disease and Alzheimer’s Disease
  • Discuss the brain microbiome and how it changes over time
  • Propose a mechanism for the oral flora influencing dementia
  • Discuss periodontal management of patients with dementia

Learning Outcomes

By the end of the presentation the participant will be able to:

  • Understand the evidence supporting a possible impact of periodontitis in Alzheimer´s disease.
  • Understand the proposed mechanisms that explain the association between periodontitis and Alzheimer´s disease. 
  • Gain knowledge of the oral microbiome in the human brain
  • Gain knowledge on the new S3 2020 guidelines on the treatment of periodontal disease.

GDC Development Outcome: C


  • Alpha Omega Members Free
  • Non-members/ guest fee £60.00 – please pay on the door
  • Undergraduates & HEE Dentists Free

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